Life sciences start-up companies face many tax-related issues. The items noted below are not all-inclusive, and not all companies will face all of these issues or opportunities. However, even in years when companies incur no tax liability because of operating losses, proper planning is important to maximize the future benefits of current investments. These issues are not unique to life sciences start-up companies, but in combination, they are not commonly incurred in other industries. Ignoring the future benefit of considering these opportunities may have significant impact on future cash flows of the company during a time that cash should be utilized for expansion and growth.